Primary cilia mediate Klf2-dependant Notch activation in regenerating heart
نویسندگان
چکیده
منابع مشابه
Primary cilia regulate Gli/Hedgehog activation in pancreas.
Previous studies have suggested that defects in pancreatic epithelium caused by activation of the Hedgehog (Hh) signaling pathway are secondary to changes in the differentiation state of the surrounding mesenchyme. However, recent results describe a role of the pathway in pancreatic epithelium, both during development and in adult tissue during neoplastic transformation. To determine the conseq...
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The zebrafish heart regenerates after ventricular damage through a process involving inflammation, fibrotic tissue deposition/removal and myocardial regeneration. Using 3D whole-mount imaging, we reveal a highly dynamic endocardium during cardiac regeneration, including changes in cell morphology, behaviour and gene expression. These events lay the foundation for an initial expansion of the end...
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ژورنال
عنوان ژورنال: Protein & Cell
سال: 2020
ISSN: 1674-800X,1674-8018
DOI: 10.1007/s13238-020-00695-w